AMANTADINE
Joel Kirschbaum
1. Introduction
1.1 History, Therapeutic Use, and Mechanism of Action
1.2 Nomenclature, Molecular Weight, and Structure
1.3 Appearance, Color, Odor, and Precautions
1.4 Synthesis
1.5 Reactions, Stability, and Metabolism
2. Physical Properties of Crystalline Amantadine
2.1 Single Crystal X-Ray Diffraction
2.2 X-Ray Powder Diffraction
2.3 Mass Spectrometry
2.4 Infrared Spectrometry
2.5 Electron Tunnelling and Photoelectron Spectrometry
2.6 Thermal Analysis
2.7 Microscopy
2.8 Surface Area
2.9 Hydration
2.10 Polymorphism
Spectrometry of Amantadine in Solution
3.1
3.2 Ultraviolet Spectrometry
4.1 Solubilities in Aqueous and Nonaqueous Solvents
4.2 Ionization
4.3 Dipole Moments
4.4 Hydrodynamic Properties
5.1 Compositional Analysis
5.2 Identity and Colorimetric Methods
5.3 Titration
5.4 Spectrometry
5.5 Gas-Liquid Chromatography
5.6 Thin-Layer Chromatography
5.7 High-Performance Liquid Chromatography
5.8 Electrochemistry
5.9 Fluorescence Spectrometry
5.10 Tissue Culture
5.11 Comparison of Methods
References
3.
Nuclear Magnetic Resonance Spectrometry (NMR)
1. Bulk Solution Properties