1. Wilson’s Disease: Current Therapies, Its Controversies, and Potential New Therapeutics
Dias Rima Sutiono, Giardani Syafitri Sudiro
Indonesia International Institute for Life Sciences (i3L), Jakarta Timur, Indonesia.
Abstract
Wilson’s Disease is a rare genetic disorder with the prevalence of 1 in every 30,000 people, due to the mutation of the ATP7B gene responsible
for copper metabolism. The mutation causes copper accumulation in the body, especially in the liver and brain, which leads to hepatic,
neurological, psychological symptoms. These symptoms, if not treated properly, may lead to death after several years. Several treatments
including low copper diet, zinc salts treatment, chelating agents (penicillamine, trientine, ammonium tetrahimiolybdate), and liver transplant
are currently available. Severe neurological deterioration and other side effects need new, more efficient, and safer therapeutics. Several new
therapeutic agents including 4-phenylbutyrate, curcumin, chelating polymeric beads, and long term metabolic correction has been tested in
vitro and in vivo. These new therapeutics may be a potential new treatment with less side effect and greater efficacy for Wilson’s disease patients.
Keywords: 4-PBA, 4-phenylbutyrate, curcumin, microbeads, Wilson’s disease
2.Marjolin’s Ulcer: Diagnosis dan Penatalaksanaan
Nyoman Siska Ananda
Fakultas Kedokteran Universitas Udayana, Denpasar, Bali, Indonesia
ABSTRAK
Marjolin’s ulcer adalah kondisi keganasan pada kulit yang sebelumnya terluka dan mengalami inflamasi kronis. Diagnosis berdasarkan anamnesis,
pemeriksaan fisik, dan biopsi yang merupakan pemeriksaan baku emas. Penatalaksanaan adalah operasi eksisi lokal dan skin graft.
Kata kunci: Diagnosis, Marjolin’s ulcer, penatalaksanaan
3.Modalitas MRI sebagai Pemeriksaan Penunjang pada Kanker Prostat
Barnabas I Wayan Tirta
Departemen Radiologi Fakultas Kedokteran Universitas Kristen Krida Wacana, Jakarta, Indonesia
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