CONTENTS
1. Description
1.1 Name, Formula, Molecular Weight
1.2 Appearance, Color
2.1 Spectra
2. Physical Properties
2.11 Infra-red Spectrum
2.12 Ultra-violet Spectrum
2.13 Fluorescence Spectrum
2.14 N.M.R. Spectrum
2.15 Mass Spectrum
2.2 Physical Properties of the Solid
2.21 Melting Characteristics
2.22 Density
2.23 Vapor Pressure and T.G.A.
2.24 D.T.A. and D.S.C.
2.25 Crystal Characteristics
2.26 X-ray Diffraction
2.31 Static Charge
2.32 Flow Properties
2.33 Compression Characteristics
2.34 Surface Area and Porosity
2.41 Solubility in Aqueous Solvents
2.42 Solubility in Water Miscible
2.43 Solubility in Solvents Immisc-
2.44 Rate of Dissolution
2.51 Cryoscopy
2.52 Ionisation and pH
2.53 Dipole Moment
2.54 Refractive Index
2.55 Adsorption from Solution
2.56 Partition Coefficients
2.3 Powder Characteristics
2.4 Solubility
Solvents
ible with Water
2.5 Physical Properties of Solutions
3. Molecular Complexes
2
ACETAMINOPHEN
4.
5.
6.
Synthesis and Purification
4.1 Chemical Synthesis
4.11 Synthetic Routes
4.12 Purification
4.13 Impurity Profile
4.14 Reference Standards
4.21 Metabolism of Phenacetin and
4.22 Prodrugs
4.23 Microbial Biosynthesis
4.2 Biosynthesis
Ace tan i 1 ide
S tabi 1 ity
5.1 Stability to Light
5.2 Stability of Solid Acetaminophen to
5.3
Heat – Stability of Solutions of Acetamino-
phen
Materials
5.4 Stability to Oxidation
5.5 Compatibility with Excipient
5.6 Compatibility with Aspirin
5.7 Physical Incompatibilities
6.1 Identity Tests
6.2 Methods of Analysis
Analytical Chemistry
6.20 Gravimetric Procedures
6.21
6.22
6.23
6.24
6.25
6.26
6.27
6.28
6.29
T itr ime t r ic Procedures
Polarographic Procedures
U.V. Spectrophotometric Pro-
cedures
Photocolorimetric Procedures
Ion-Exchange Chromatrographic
Procedures
Partition Chromatographic Pro-
cedur es
Paper and Thin-Layer Chromato-
graphic Procedures
Vapor’ Phase Chromatographic
Procedures
High – Pressure Liquid Chrom-
atographic and Gel Filtration
Procedures
6.3 Automated Procedures
6.4 Radiochemical Procedures
3
JOHN E. FAIRBROTHER
6.5
6.6
Determination
Degradation Products
7 of Acetam
of Trace Impurities and
i nophen and
Luids and
Tissues
6.61 Determination in Urine
6.62 Determination in Serum, Plasma
and Whole Blood
6.63 Determination in Tissues and
Orsans
7. Metabolic Transzormations
7.1 Metabolism in Man
7.11 Adults
7.12 Newborn Infants
7.2 Metabolism in Animals
8.1 Pharmacokinetics
8.2 Protein Binding
8.3 Interactions with Other D,rug Sub-
8.4 Biopharmaceutics
8. Drug Availability
stances
9. Toxicity
