CONTENTS

T. A. PLOMP

Introduction
1. Description
1.1. Nomenclature
1.2. Formulae
1.3. Molecular weight
1.4. Elemental composition
1.5. Appearance, Color, Odor and Taste
1.6. Dosage forms
2. Physical properties
2.1. Melting point and melting range
2.2. Solubility
2.3. pH-value
2.4. Loss on Drying
2.5. Dissociation constant
2.6. Partition coefficient
2.7. Stability
2.8. Incompatiblity
2.9. Spectral properties
3. Synthesis
4. Methods of analysis in raw materials and pharmaceutical formulations
4.1. Identification Tests
4.2. Titrimetric Analyses
4.3. Spectrophotometric Analysis
4.4. Chromatographic Analyses

AMIODARONE 3

5. Methods of analysis in biological fluids and tissues
5.1. High-performance thin-layer chromatography
5.2. High-performance liquid chromatography/mass spectrometry
5.3. High-performance liquid chromatography
6. Pharmacokinetics and Metabolism
6.1. Pharmacokinetic studies in man
6.2. Metabolism and urinary excretion
6.3. Excretion in other biological fluids

 

DOWNLOAD