JAGDISH PARASRAMPURIA
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I NTRODUCTI ON
1.1 History
1.2 Therapeutic Category
1.3 Chemistry and Structure-Activity
2.1 Name, Formula, and Molecular Weight
2.2 Appearance, Color, Odor, and Taste
2.3 Pharmaceutical Dosage Forms
3.1 Dissociation Constant (pKa)
3.2 U1 traviolet Spectra
3.3 Solubility
3.3.1 pH-Sol ubil i ty Prof i 1 e
3.3.2 Solubility in Various Commonly Used
3 -3 -3 Sol ubi 1 i zation through Cosol vency
Re1 ati onshi p
DESCRIPTION
PHYSICAL PROPERTIES
Pharmaceutical Sol vents
3.4 Polymorphism
3.5 Melting Point
3.6 Differential Scanning Calorimetry
3.7 Infrared Spectra
3.8 X-Ray Diffraction
3.9 Nuclear Magnetic Resonance Spectra
4.1 Identification Tests
4.2 U1 traviolet Spectroscopy
4.3 Pol arography
4.4 Nuclear Magnetic Resonance Spectroscopy
4.5 Chromatography
METHODS OF ANALYSIS
4.5.1 High-Performance Liquid
4.5.2 Gas Liquid Chromatography
Chromatography
STAB I L I TY
5.1 pH-Rate Profile
5.2 Stability in Intravenous Admixtures
5.3 Effect of Temperature
5.4 Effect of Buffer Species, Buffer
5.5 Stability in Various Solvents
BIOPHARMACEUTICS
6.1 Pharmacokinetics and Metabolism
6.2
Concentration, and Ionic Strength
Bi oavai 1 abi 1 i ty
REFERENCES
